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herg human potassium ion channel [3h] dofetilide binding (antagonist radioligand) assay  (Eurofins)
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herg ion channel  (SB Drug Discovery)
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HEK <t>and</t> <t>CHO</t> cells recorded in standard and fluoride-free internal solution. (A) HEK cells expressing <t>hERG</t> were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Tail > 150 pA and almost 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Tail > 150 pA was used, the success rate was increased in both conditions (right). (B) CHO cells expressing Na V 1.5 were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Peak < –100 pA and over 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Peak < –100 pA was used, the success rate was increased in both conditions (right). (C) Histogram plot of the R Seal values for HEK-hERG cells in standard and fluoride-free internal solution. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal . (D) Histogram plot of the R Seal values for CHO-Na V 1.5 cells in standard and fluoride-free internal. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal .
Herg Ion Channel, supplied by SB Drug Discovery, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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herg human potassium ion channel [3h] dofetilide binding item 4094  (Eurofins)
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HEK <t>and</t> <t>CHO</t> cells recorded in standard and fluoride-free internal solution. (A) HEK cells expressing <t>hERG</t> were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Tail > 150 pA and almost 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Tail > 150 pA was used, the success rate was increased in both conditions (right). (B) CHO cells expressing Na V 1.5 were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Peak < –100 pA and over 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Peak < –100 pA was used, the success rate was increased in both conditions (right). (C) Histogram plot of the R Seal values for HEK-hERG cells in standard and fluoride-free internal solution. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal . (D) Histogram plot of the R Seal values for CHO-Na V 1.5 cells in standard and fluoride-free internal. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal .
Herg Human Potassium Ion Channel [3h] Dofetilide Binding Item 4094, supplied by Eurofins, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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herg ion channel assay  (WuXi AppTec)
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HEK <t>and</t> <t>CHO</t> cells recorded in standard and fluoride-free internal solution. (A) HEK cells expressing <t>hERG</t> were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Tail > 150 pA and almost 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Tail > 150 pA was used, the success rate was increased in both conditions (right). (B) CHO cells expressing Na V 1.5 were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Peak < –100 pA and over 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Peak < –100 pA was used, the success rate was increased in both conditions (right). (C) Histogram plot of the R Seal values for HEK-hERG cells in standard and fluoride-free internal solution. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal . (D) Histogram plot of the R Seal values for CHO-Na V 1.5 cells in standard and fluoride-free internal. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal .
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HEK <t>and</t> <t>CHO</t> cells recorded in standard and fluoride-free internal solution. (A) HEK cells expressing <t>hERG</t> were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Tail > 150 pA and almost 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Tail > 150 pA was used, the success rate was increased in both conditions (right). (B) CHO cells expressing Na V 1.5 were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Peak < –100 pA and over 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Peak < –100 pA was used, the success rate was increased in both conditions (right). (C) Histogram plot of the R Seal values for HEK-hERG cells in standard and fluoride-free internal solution. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal . (D) Histogram plot of the R Seal values for CHO-Na V 1.5 cells in standard and fluoride-free internal. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal .
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HEK and CHO cells recorded in standard and fluoride-free internal solution. (A) HEK cells expressing hERG were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Tail > 150 pA and almost 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Tail > 150 pA was used, the success rate was increased in both conditions (right). (B) CHO cells expressing Na V 1.5 were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Peak < –100 pA and over 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Peak < –100 pA was used, the success rate was increased in both conditions (right). (C) Histogram plot of the R Seal values for HEK-hERG cells in standard and fluoride-free internal solution. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal . (D) Histogram plot of the R Seal values for CHO-Na V 1.5 cells in standard and fluoride-free internal. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal .

Journal: Frontiers in Molecular Neuroscience

Article Title: There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments

doi: 10.3389/fnmol.2022.982316

Figure Lengend Snippet: HEK and CHO cells recorded in standard and fluoride-free internal solution. (A) HEK cells expressing hERG were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Tail > 150 pA and almost 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Tail > 150 pA was used, the success rate was increased in both conditions (right). (B) CHO cells expressing Na V 1.5 were captured with almost 80% success rate for R Seal ≥ 1 GΩ + I Peak < –100 pA and over 40% success rate for R Seal ≥ 1 GΩ in fluoride-free internal solution (left). If a QC cutoff of R Seal ≥ 0.25 GΩ + I Peak < –100 pA was used, the success rate was increased in both conditions (right). (C) Histogram plot of the R Seal values for HEK-hERG cells in standard and fluoride-free internal solution. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal . (D) Histogram plot of the R Seal values for CHO-Na V 1.5 cells in standard and fluoride-free internal. For R Seal > 4 GΩ, although they are high giga-seals, the seal resistance is not accurately calculated and is therefore shown as an extra bar and these R Seal values were not included in the calculation for R Seal .

Article Snippet: We demonstrate this using the ion channels Na V 1.5 and Na V 1.7 expressed in CHO (Charles River), hERG expressed in HEK293 (SB Drug Discovery), and K Ca 3.1 (SK4) also expressed in CHO cells (Charles River).

Techniques: Expressing

ADMET prediction of selected compounds

Journal: In Silico Pharmacology

Article Title: In silico investigation of saponins and tannins as potential inhibitors of SARS-CoV-2 main protease (M pro )

doi: 10.1007/s40203-020-00071-w

Figure Lengend Snippet: ADMET prediction of selected compounds

Article Snippet: Comparison of ADMET profile of the hits with the standard drugs revealed that Remdesivir, Dexamethasone, and N3 inhibitor had good ADMET profiles, but both dexamethasone and N3 inhibitor were found to be blockers of hERG potassium ion channel while Remdesivir is not.

Techniques: Solubility, Mutagenesis, Inhibition